Protein-to-mRNA ratios are conserved between Pseudomonas aeruginosa strains.

ABSTRACT: Recent studies have shown that the concentrations of proteins expressed from orthologous genes are often conserved across organisms and to a greater extent than the abundances of the corresponding mRNAs. However, such studies have not distinguished between evolutionary (e.g., sequence divergence) and environmental (e.g., growth condition) effects on the regulation of steady-state protein and mRNA abundances. Here, we systematically investigated the transcriptome and proteome of two closely related Pseudomonas aeruginosa strains, PAO1 and PA14, under identical experimental conditions, thus controlling for environmental effects. For 703 genes observed by both shotgun proteomics and microarray experiments, we found that the protein-to-mRNA ratios are highly correlated between orthologous gene

SUBMITTER: Kwon T 

PROVIDER: S-EPMC4012837 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature