Genetic risk score of NOS gene variants associated with myocardial infarction correlates with coronary incidence across Europe.

ABSTRACT: Coronary artery disease (CAD) mortality and morbidity is present in the European continent in a four-fold gradient across populations, from the South (Spain and France) with the lowest CAD mortality, towards the North (Finland and UK). This observed gradient has not been fully explained by classical or single genetic risk factors, resulting in some cases in the so called Southern European or Mediterranean paradox. Here we approached population genetic risk estimates using genetic risk scores (GRS) constructed with single nucleotide polymorphisms (SNP) from nitric oxide synthases (NOS) genes. These SNPs appeared to be associated with myocardial infarction (MI) in 2165 cases and 2153 controls. The GRSs were computed in 34 general European populations. Although the contribution of these GRS w

SUBMITTER: Carreras-Torres R 

PROVIDER: S-EPMC4013019 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature