An oocyte-specific ELAVL2 isoform is a translational repressor ablated from meiotically competent antral oocytes.

ABSTRACT: At the end of the growth phase, mouse antral follicle oocytes acquire full developmental competence. In the mouse, this event is marked by the transition from the so-called non-surrounded nucleolus (NSN) chromatin configuration into the transcriptionally quiescent surrounded nucleolus (SN) configuration, which is named after a prominent perinucleolar condensed chromatin ring. However, the SN chromatin configuration alone is not sufficient for determining the developmental competence of the SN oocyte. There are additional nuclear and cytoplamic factors involved, while a little is known about the changes occurring in the cytoplasm during the NSN/SN transition. Here, we report functional analysis of maternal ELAVL2 an AU-rich element binding protein. Elavl2 gene encodes an oocyte-specific pro

SUBMITTER: Chalupnikova K 

PROVIDER: S-EPMC4013169 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature