Comparing the efficacy of efavirenz and boosted lopinavir using viremia copy-years.

ABSTRACT:

Introduction

HIV-1 plasma viral load during treatment can be highly variable. Thus, there is the need to find a measure of cumulative viremia that can be used to assess both the short- and long-term efficacy of highly active antiretroviral therapy (HAART). Here, we validate a measure of cumulative viremia to evaluate HAART efficacy.

Methods

We accessed HAART efficacy using data from a randomized clinical trial conducted in Mexico. We compared the proportion of individuals achieving a viral load <50 and <400 copies/mL at week 48, against the cumulative plasma viral load, estimated as the area under the plasma viral load curve (AUVLC). High AUVLC indicates high cumulative viremia.

Results and discussion

There was a strong and significant association between the proporti

SUBMITTER: Lima VD 

PROVIDER: S-EPMC4013478 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature