Interaction of neuropeptide Y genotype and childhood emotional maltreatment on brain activity during emotional processing.

ABSTRACT: Neuropeptide Y (NPY) has been associated with stress reactivity in affective disorders and is most densely expressed in the amygdala. An important stressor associated with affective disorders is the experience of childhood emotional maltreatment (CEM). We investigated whether the interaction of NPY risk genotype and CEM would affect brain activation. From The Netherlands Study of Depression and Anxiety, 33 healthy controls and 85 patients with affective disorders were scanned with functional magnetic resonance imaging while making gender decisions of emotional facial expressions. Results showed interactions between genotype and CEM, within carriers of the risk genotype, CEM was associated with higher amygdala activation, whereas CEM did not influence activation in non-risk carriers. In the

SUBMITTER: Opmeer EM 

PROVIDER: S-EPMC4014098 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature