Dysregulation of microRNA biosynthesis enzyme Dicer plays an important role in gastric cancer progression.

ABSTRACT:

Background and aim

Dicer is one of the most important components in microRNA biogenesis. Although studies have revealed the aberrantly expression of Dicer in types of cancer, the results were greatly controversial. Here we aimed to study the expression of Dicer in gastric cancer (GC) and further explored the possible roles of Dicer in cancer progression.

Methods

The alteration of Dicer-expression in GC and its clinical significance was retrospectively studied with immunohistochemical analyses on 377 cases of cancer tissues using tissue microarray (TMA). Dicer mRNA and protein levels were also examined in 8 paired of GC tissues and non-neoplastic surrounding gastric epithelium with real time RT-PCR and western blot.

Results

We found that Dicer was reduced in GC tissues

SUBMITTER: Zhang J 

PROVIDER: S-EPMC4014251 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature