Effects of irbesartan on serum uric acid levels in patients with hypertension and diabetes.

ABSTRACT:

Background

Hyperuricemia has been proposed to be a risk factor for cardiovascular disease and chronic kidney disease. Since diabetes is often complicated by hypertension and hyperuricemia, efficient therapeutic strategy against these two complications is very important in diabetic treatment. It has been reported that the antihypertensive drug, irbesartan, inhibits the renal uric acid reabsorptive transporters, URAT1 and GLUT9; this result suggests that irbesartan decreases serum uric acid level (SUA).

Subjects and methods

A retrospective study of 107 patients with hypertension and diabetes was performed to analyze the effects of irbesartan on blood pressure, estimated glomerular filtration rate (eGFR), and SUA. The follow-up period was 6-12 months. Seventy percent of the pat

SUBMITTER: Nakamura M 

PROVIDER: S-EPMC4014383 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature