Synonymous constraint elements show a tendency to encode intrinsically disordered protein segments.

ABSTRACT: Synonymous constraint elements (SCEs) are protein-coding genomic regions with very low synonymous mutation rates believed to carry additional, overlapping functions. Thousands of such potentially multi-functional elements were recently discovered by analyzing the levels and patterns of evolutionary conservation in human coding exons. These elements provide a good opportunity to improve our understanding of how the redundant nature of the genetic code is exploited in the cell. Our premise is that the protein segments encoded by such elements might better comply with the increased functional demands if they are structurally less constrained (i.e. intrinsically disordered). To test this idea, we investigated the protein segments encoded by SCEs with computational tools to describe the underly

SUBMITTER: Macossay-Castillo M 

PROVIDER: S-EPMC4014394 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature