Genetic dissection of the Drosophila melanogaster female head transcriptome reveals widespread allelic heterogeneity.

ABSTRACT: Modern genetic mapping is plagued by the "missing heritability" problem, which refers to the discordance between the estimated heritabilities of quantitative traits and the variance accounted for by mapped causative variants. One major potential explanation for the missing heritability is allelic heterogeneity, in which there are multiple causative variants at each causative gene with only a fraction having been identified. The majority of genome-wide association studies (GWAS) implicitly assume that a single SNP can explain all the variance for a causative locus. However, if allelic heterogeneity is prevalent, a substantial amount of genetic variance will remain unexplained. In this paper, we take a haplotype-based mapping approach and quantify the number of alleles segregating at each lo

SUBMITTER: King EG 

PROVIDER: S-EPMC4014434 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature