Transcriptional and proteomic responses to carbon starvation in Paracoccidioides.

ABSTRACT:

Background

The genus Paracoccidioides comprises human thermal dimorphic fungi, which cause paracoccidioidomycosis (PCM), an important mycosis in Latin America. Adaptation to environmental conditions is key to fungal survival during human host infection. The adaptability of carbon metabolism is a vital fitness attribute during pathogenesis.

Methodology/principal findings

The fungal pathogen Paracoccidioides spp. is exposed to numerous adverse conditions, such as nutrient deprivation, in the human host. In this study, a comprehensive response of Paracoccidioides, Pb01, under carbon starvation was investigated using high-resolution transcriptomic (RNAseq) and proteomic (NanoUPLC-MSE) approaches. A total of 1,063 transcripts and 421 proteins were differentially regulated, provid

SUBMITTER: Lima Pde S 

PROVIDER: S-EPMC4014450 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature