Visual scoring of non cavitated caries lesions and clinical trial efficiency, testing xylitol in caries-active adults.

ABSTRACT:

Objectives

To better understand the effectiveness of xylitol in caries prevention in adults and to attempt improved clinical trial efficiency.

Methods

As part of the Xylitol for Adult Caries Trial (X-ACT), non cavitated and cavitated caries lesions were assessed in subjects who were experiencing the disease. The trial was a test of the effectiveness of 5 g/day of xylitol, consumed by dissolving in the mouth five 1 g lozenges spaced across each day, compared with a sucralose placebo. For this analysis, seeking trial efficiency, 538 subjects aged 21-80, with complete data for four dental examinations, were selected from the 691 randomized into the 3-year trial, conducted at three sites. Acceptable inter- and intra-examiner reliability before and during the trial was quantified

SUBMITTER: Brown JP 

PROVIDER: S-EPMC4014519 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature