Standardizing benchmark dose calculations to improve science-based decisions in human health assessments.

ABSTRACT:

Background

Benchmark dose (BMD) modeling computes the dose associated with a prespecified response level. While offering advantages over traditional points of departure (PODs), such as no-observed-adverse-effect-levels (NOAELs), BMD methods have lacked consistency and transparency in application, interpretation, and reporting in human health assessments of chemicals.

Objectives

We aimed to apply a standardized process for conducting BMD modeling to reduce inconsistencies in model fitting and selection.

Methods

We evaluated 880 dose-response data sets for 352 environmental chemicals with existing human health assessments. We calculated benchmark doses and their lower limits [10% extra risk, or change in the mean equal to 1 SD (BMD/L10/1SD)] for each chemical in a stand

SUBMITTER: Wignall JA 

PROVIDER: S-EPMC4014768 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature