GATA-3 expression identifies a high-risk subset of PTCL, NOS with distinct molecular and clinical features.

ABSTRACT: The cell of origin and the tumor microenvironment's role remain elusive for the most common peripheral T-cell lymphomas (PTCLs). As macrophages promote the growth and survival of malignant T cells and are abundant constituents of the tumor microenvironment, their functional polarization was examined in T-cell lymphoproliferative disorders. Cytokines that are abundant within the tumor microenvironment, particularly interleukin (IL)-10, were observed to promote alternative macrophage polarization. Macrophage polarization was signal transducer and activator of transcription 3 dependent and was impaired by the Janus kinase inhibitor ruxolitinib. In conventional T cells, the production of T helper (Th)2-associated cytokines and IL-10, both of which promote alternative macrophage polarization, i

SUBMITTER: Wang T 

PROVIDER: S-EPMC4014843 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature