Intraclonal variations among Streptococcus pneumoniae isolates influence the likelihood of invasive disease in children.

ABSTRACT:

Background

Pneumococcal serotypes are represented by a varying number of clonal lineages with different genetic contents, potentially affecting invasiveness. However, genetic variation within the same genetic lineage may be larger than anticipated.

Methods

A total of 715 invasive and carriage isolates from children in the same region and during the same period were compared using pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing. Bacterial genome sequencing, functional assays, and in vivo virulence mice studies were performed.

Results

Clonal types of the same serotype but also intraclonal variants within clonal complexes (CCs) showed differences in invasive-disease potential. CC138, a common CC, was divided into several PFGE patterns, partly expla

SUBMITTER: Browall S 

PROVIDER: S-EPMC4014860 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature