Hemoglobin A1c for the diagnosis of diabetes: To replace or to guide oral glucose tolerance tests?

ABSTRACT:

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Aims/Introduction:  To evaluate if hemoglobin A1c (A1C) can replace the use of the oral glucose tolerance test (OGTT) to diagnose diabetes in Chinese patients.

Materials and methods

  Subjects without pre-existing diabetes were included in this community-based study. Each participant received a 75-g OGTT and A1C tests.

Results

  A total of 1362 subjects, 512 men and 850 women, aged 18-88 years, were enrolled. The prevalence of diabetes was 7.4 and 7.3% by OGTT and by A1C ≥ 6.5% criteria, respectively. The optimal A1C cut-off for diabetes defined by OGTT was 6.1%. The performance of A1C ≥ 6.1% to find diabetes by OGTT was poor, with a kappa 0.50, sensitivity 80% and specificity 91%. Using current criteria of fasting plasma glucose (FPG) < 5.56 mmol/L to excl

SUBMITTER: Li HY 

PROVIDER: S-EPMC4014947 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature