ProphNet: a generic prioritization method through propagation of information.

ABSTRACT:

Background

Prioritization methods have become an useful tool for mining large amounts of data to suggest promising hypotheses in early research stages. Particularly, network-based prioritization tools use a network representation for the interactions between different biological entities to identify novel indirect relationships. However, current network-based prioritization tools are strongly tailored to specific domains of interest (e.g. gene-disease prioritization) and they do not allow to consider networks with more than two types of entities (e.g. genes and diseases). Therefore, the direct application of these methods to accomplish new prioritization tasks is limited.

Results

This work presents ProphNet, a generic network-based prioritization tool that allows to integrat

SUBMITTER: Martinez V 

PROVIDER: S-EPMC4015146 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature