Responses to enteric motor neurons in the gastric fundus of mice with reduced intramuscular interstitial cells of cajal.

ABSTRACT:

Background/aims

Interstitial cells of Cajal (ICC) play important functions in motor activity of the gastrointestinal tract. The role of ICC as pace-makers is well established, however their participation in neurotransmission is controversial. Studies using mutant animals that lack ICC have yielded variable conclusions on their importance in enteric motor responses. The purpose of this study was to: (1) clarify the role of intramuscular ICC (ICC-IM) in gastric motor-neurotransmission and (2) evaluate remodeling of enteric mo-tor responses in W/W(V) mice.

Methods

Kit immunohistochemistry and post-junctional contractile responses were performed on fundus muscles from wild-type and W/W(V) mice and quantitative polymerase chain reaction (qPCR) was used to evaluate differences in

SUBMITTER: Sanders KM 

PROVIDER: S-EPMC4015192 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature