Nine scoring models for short-term mortality in alcoholic hepatitis: cross-validation in a biopsy-proven cohort.

ABSTRACT:

Background

Several prognostic models have emerged in alcoholic hepatitis (AH), but lack of external validation precludes their universal use.

Aim

To validate the Maddrey Discriminant Function (DF); Glasgow Alcoholic Hepatitis Score (GAHS); Mayo End-stage Liver Disease (MELD); Age, Bilirubin, INR, Creatinine (ABIC); MELD-Na, UK End-stage Liver Disease (UKELD), and three scores of corticosteroid response at 1 week: an Early Change in Bilirubin Levels (ECBL), a 25% fall in bilirubin, and the Lille score.

Methods

Seventy-one consecutive patients with biopsy-proven AH, admitted between November 2007-September 2011, were evaluated. The clinical and biochemical parameters were analysed to assess prognostic models with respect to 30- and 90-day mortality.

Results

There

SUBMITTER: Papastergiou V 

PROVIDER: S-EPMC4015369 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature