Severity of obstructive sleep apnea is associated with cardiac troponin I concentrations in a community-based sample: data from the Akershus Sleep Apnea Project.

ABSTRACT:

Objectives

Previous community-based studies have failed to demonstrate an independent association between OSA and circulating cardiac troponin concentrations, a marker of myocardial injury. However, these studies have used troponin assays with modest analytic sensitivity to detect low-level, chronic increments in troponin levels. Using a highly sensitive troponin I (hs-TnI) assay, we tested the hypothesis that the severity of OSA is associated with myocardial injury independently of comorbidities.

Design

Cross-sectional study.

Setting

Community-based.

Participants

514 subjects (54% men, age 48 ± 11 y [mean ± SD]).

Interventions

N/A.

Measurements and results

hs-TnI concentrations were measured in fasting morning blood samples and 318 participants (

SUBMITTER: Einvik G 

PROVIDER: S-EPMC4015385 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature