Dataset Information

BCG vaccination in patients with severe combined immunodeficiency: complications, risks, and vaccination policies.

ABSTRACT:

Background

Severe combined immunodeficiency (SCID) is a syndrome characterized by profound T-cell deficiency. BCG vaccine is contraindicated in patients with SCID. Because most countries encourage BCG vaccination at birth, a high percentage of patients with SCID are vaccinated before their immune defect is detected.

Objectives

We sought to describe the complications and risks associated with BCG vaccination in patients with SCID.

Methods

An extensive standardized questionnaire evaluating complications, therapeutics, and outcomes regarding BCG vaccination in patients given a diagnosis of SCID was widely distributed. Summary statistics and association analysis was performed.