General and specific functional connectivity disturbances in first-episode schizophrenia during cognitive control performance.

ABSTRACT:

Background

Cognitive control impairments in schizophrenia are thought to arise from dysfunction of interconnected networks of brain regions, but interrogating the functional dynamics of large-scale brain networks during cognitive task performance has proved difficult. We used functional magnetic resonance imaging to generate event-related whole-brain functional connectivity networks in participants with first-episode schizophrenia and healthy control subjects performing a cognitive control task.

Methods

Functional connectivity during cognitive control performance was assessed between each pair of 78 brain regions in 23 patients and 25 control subjects. Network properties examined were region-wise connectivity, edge-wise connectivity, global path length, clustering, small-wor

SUBMITTER: Fornito A 

PROVIDER: S-EPMC4015465 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature