Differential enrichment of regulatory motifs in the composite network of protein-protein and gene regulatory interactions.

ABSTRACT:

Background

An important aspect of molecular interactions is the dynamics associated with growth conditions. Intuitively, not all possible interactions take place together all the time in a cell as only a subset of genes is expressed based on environmental conditions.

Results

Large scale gene expression data of Escherichia coli was analyzed to understand the dynamics exhibited at expression level. A large compendium of gene expression datasets, which covers about 466 growth conditions, was used for the analysis. Using gene expression data, genes of E. coli were profiled into three classes: Widely expressed, Conditionally expressed and Rarely expressed. Further, dynamics associated with molecular interactions were analysed by studying changing importance of motifs in the compo

SUBMITTER: Hegde SR 

PROVIDER: S-EPMC4015501 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature