Exploring evolution of brain genes involved in microcephaly through phylogeny and synteny analysis.

ABSTRACT:

Background

Human brain development is a complicated process. When normal growth and development of brain or central nervous system is impaired, it leads to neurodevelopemental disorders (NDDs). Autosomal Recessive Primary Microcephaly (MCPH) is one of those, for which seven loci (MCPH1-MCPH7) with the corresponding genes (MCPH1, WDR62, CDK5RAP2, CEP152, ASPM, CENPJ, and STIL) have been reported so far. An important field of study is to find out diversity among organisms due to evolution. How species are related to each other can be inferred through finding evolutionary relationship between organisms in the form of ancestors and descendents.

Methods

MEGA5 was used for phylogenetic tree reconstruction. Pair-wise and multiple alignment was built through ClustalW algorithm. Neig

SUBMITTER: Rauf S 

PROVIDER: S-EPMC4015606 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature