Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy.

ABSTRACT: Sexually dimorphic mammalian tissues, including sexual organs and the brain, contain stem cells that are directly or indirectly regulated by sex hormones. An important question is whether stem cells also exhibit sex differences in physiological function and hormonal regulation in tissues that do not show sex-specific morphological differences. The terminal differentiation and function of some haematopoietic cells are regulated by sex hormones, but haematopoietic stem-cell function is thought to be similar in both sexes. Here we show that mouse haematopoietic stem cells exhibit sex differences in cell-cycle regulation by oestrogen. Haematopoietic stem cells in female mice divide significantly more frequently than in male mice. This difference depends on the ovaries but not the testes. Admin

SUBMITTER: Nakada D 

PROVIDER: S-EPMC4015622 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature