Clinical outcomes for patients with metastatic renal cell carcinoma treated with alternative sunitinib schedules.

ABSTRACT:

Purpose

We identified sunitinib alternative schedules that maintained dose intensity while decreasing adverse events in patients with metastatic renal cell cancer. We also determined the impact of alternative schedules on clinical outcomes.

Materials and methods

We retrospectively reviewed the records of patients 18 years old or older with clear cell metastatic renal cell cancer who received first line sunitinib between January 26, 2006 and March 1, 2011 at our major comprehensive cancer center. A subset of patients was switched at the first intolerable adverse event from the traditional schedule of 28 days on and 14 days off to a schedule of 14 days on and 7 days off or other alternative schedules. A control group underwent standard dose reduction. We estimated progression-

SUBMITTER: Atkinson BJ 

PROVIDER: S-EPMC4015627 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature