Genome-wide two-marker linkage disequilibrium mapping of quantitative trait loci.

ABSTRACT:

Background

In a natural population, the alleles of multiple tightly linked loci on the same chromosome co-segregate and are passed non-randomly from generation to generation. Capitalizing on this phenomenon, a group of mapping methods, commonly referred to as the linkage disequilibrium-based mapping (LD mapping), have been developed recently for detecting genetic associations. However, most current LD mapping methods mainly employed single-marker analysis, overlooking the rich information contained within adjacent linked loci.

Results

We extend the single-marker LD mapping to include two linked loci and explicitly incorporate their LD information into genetic mapping models (tmLD). We establish the theoretical foundations for the tmLD mapping method and also provide a thorou

SUBMITTER: Yang J 

PROVIDER: S-EPMC4015628 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature