MRNA translation and protein synthesis: an analysis of different modelling methodologies and a new PBN based approach.

ABSTRACT:

Background

mRNA translation involves simultaneous movement of multiple ribosomes on the mRNA and is also subject to regulatory mechanisms at different stages. Translation can be described by various codon-based models, including ODE, TASEP, and Petri net models. Although such models have been extensively used, the overlap and differences between these models and the implications of the assumptions of each model has not been systematically elucidated. The selection of the most appropriate modelling framework, and the most appropriate way to develop coarse-grained/fine-grained models in different contexts is not clear.

Results

We systematically analyze and compare how different modelling methodologies can be used to describe translation. We define various statistically equival

SUBMITTER: Zhao YB 

PROVIDER: S-EPMC4015640 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature