Information compression exploits patterns of genome composition to discriminate populations and highlight regions of evolutionary interest.

ABSTRACT:

Background

Genomic information allows population relatedness to be inferred and selected genes to be identified. Single nucleotide polymorphism microarray (SNP-chip) data, a proxy for genome composition, contains patterns in allele order and proportion. These patterns can be quantified by compression efficiency (CE). In principle, the composition of an entire genome can be represented by a CE number quantifying allele representation and order.

Results

We applied a compression algorithm (DEFLATE) to genome-wide high-density SNP data from 4,155 human, 1,800 cattle, 1,222 sheep, 81 dogs and 49 mice samples. All human ethnic groups can be clustered by CE and the clusters recover phylogeography based on traditional fixation index (FST) analyses. CE analysis of other mammals resul

SUBMITTER: Hudson NJ 

PROVIDER: S-EPMC4015654 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature