Expression analysis of genes and pathways associated with liver metastases of the uveal melanoma.

ABSTRACT:

Background

Uveal melanoma is an aggressive cancer which has a high percentage metastasizing to the liver, with a worse prognosis. Identification of patients at high risk of metastases may provide information for early detection of metastases and treatment.

Methods

Expression profiling of ocular tumor tissues from 46 liver metastatic uveal melanoma samples and 45 non-metastatic uveal melanoma samples were got from GEO database. Bioinformatic analyses such as the Gene Oncology and Kyoto Encyclopedia of Genes and Genomes were used to identify genes and pathways specifically associated with liver metastases of the uveal melanoma.

Results

A total of 1138 probes were differentially expressed in two group samples. All differential gene interactions in the Signal-Net were ana

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC4015751 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature