Creation of a federated database of blood proteins: a powerful new tool for finding and characterizing biomarkers in serum.

ABSTRACT: Protein biomarkers offer major benefits for diagnosis and monitoring of disease processes. Recent advances in protein mass spectrometry make it feasible to use this very sensitive technology to detect and quantify proteins in blood. To explore the potential of blood biomarkers, we conducted a thorough review to evaluate the reliability of data in the literature and to determine the spectrum of proteins reported to exist in blood with a goal of creating a Federated Database of Blood Proteins (FDBP). A unique feature of our approach is the use of a SQL database for all of the peptide data; the power of the SQL database combined with standard informatic algorithms such as BLAST and the statistical analysis system (SAS) allowed the rapid annotation and analysis of the database without the need

SUBMITTER: Marshall J 

PROVIDER: S-EPMC4015845 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature