Association of GGCX gene polymorphism with warfarin dose in atrial fibrillation population in Xinjiang.

ABSTRACT:

Objective

To study the effects of γ-glutamyl carboxylase (GGCX) rs2592551 polymorphism on warfarin dose in atrial fibrillation patients in Xinjiang region.

Methods

Polymerase chain reaction - restriction fragment length polymorphism and direct sequencing methods were used to detect the rs2592551 genotype in 269 atrial fibrillation patients with warfarin administration. The effects of different genotypes on warfarin dose were statistically analyzed.

Results

The rs2592551 polymorphism detection results were 136 cases of wild-type homozygous CC genotype (50.56%), 115 cases of heterozygous CT genotype (42.75%), 18 cases of homozygous TT genotype (6.69%). The allele frequency C was 71.93%, T was 28.07%. The stable warfarin dose average was 2.86 ± 0.61 mg/d in patients with

SUBMITTER: Kamali X 

PROVIDER: S-EPMC4015881 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature