Reconstruction of the experimentally supported human protein interactome: what can we learn?

ABSTRACT:

Background

Understanding the topology and dynamics of the human protein-protein interaction (PPI) network will significantly contribute to biomedical research, therefore its systematic reconstruction is required. Several meta-databases integrate source PPI datasets, but the protein node sets of their networks vary depending on the PPI data combined. Due to this inherent heterogeneity, the way in which the human PPI network expands via multiple dataset integration has not been comprehensively analyzed. We aim at assembling the human interactome in a global structured way and exploring it to gain insights of biological relevance.

Results

First, we defined the UniProtKB manually reviewed human "complete" proteome as the reference protein-node set and then we mined five major so

SUBMITTER: Klapa MI 

PROVIDER: S-EPMC4015887 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature