Follow-up of a major psychosis linkage site in 13q13-q14 reveals significant association in both case-control and family samples.

ABSTRACT:

Background

We previously reported a genome-wide significant linkage for major psychosis in chromosome 13q13-q14.

Methods

An association analysis was conducted in 247 unrelated DSM-IV schizophrenia (SZ) patients and 250 unrelated control subjects from the Eastern Quebec population genotyped with 2150 single nucleotide polymorphisms in 13q13-q14. We also used the kindred sample where linkage was detected (125 SZ, 120 bipolar disorder [BD] and 36 schizoaffective disorder patients vs. 467 unaffected adult relatives) for replication.

Results

An association of the T allele of rs1156026 found in the case-control sample (odds ratio [OR] = 1.81, p = 4 × 10(-6), false discovery rate = .01) was replicated in the kindred sample (OR = 1.54, p = .01), strengthening the overall asso

SUBMITTER: Bureau A 

PROVIDER: S-EPMC4015946 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature