Deeper penetration of erythrocytes into the endothelial glycocalyx is associated with impaired microvascular perfusion.

ABSTRACT: Changes in endothelial glycocalyx are one of the earliest changes in development of cardiovascular disease. The endothelial glycocalyx is both an important biological modifier of interactions between flowing blood and the vessel wall, and a determinant of organ perfusion. We hypothesize that deeper penetration of erythrocytes into the glycocalyx is associated with reduced microvascular perfusion. The population-based prospective cohort study (the Netherlands Epidemiology of Obesity [NEO] study) includes 6,673 middle-aged individuals (oversampling of overweight and obese individuals). Within this cohort, we have imaged the sublingual microvasculature of 915 participants using sidestream darkfield (SDF) imaging together with a recently developed automated acquisition and analysis approach. P

SUBMITTER: Lee DH 

PROVIDER: S-EPMC4015985 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature