Visualisation of time-varying respiratory system elastance in experimental ARDS animal models.

ABSTRACT:

Background

Patients with acute respiratory distress syndrome (ARDS) risk lung collapse, severely altering the breath-to-breath respiratory mechanics. Model-based estimation of respiratory mechanics characterising patient-specific condition and response to treatment may be used to guide mechanical ventilation (MV). This study presents a model-based approach to monitor time-varying patient-ventilator interaction to guide positive end expiratory pressure (PEEP) selection.

Methods

The single compartment lung model was extended to monitor dynamic time-varying respiratory system elastance, Edrs, within each breathing cycle. Two separate animal models were considered, each consisting of three fully sedated pure pietrain piglets (oleic acid ARDS and lavage ARDS). A staircase recruit

SUBMITTER: van Drunen EJ 

PROVIDER: S-EPMC4016000 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature