A comparative study of ribosomal proteins: linkage between amino acid distribution and ribosomal assembly.

ABSTRACT:

Background

Assembly of the ribosome from its protein and RNA constituents must occur quickly and efficiently in order to synthesize the proteins necessary for all cellular activity. Since the early 1960's, certain characteristics of possible assembly pathways have been elucidated, yet the mechanisms that govern the precise recognition events remain unclear.We utilize a comparative analysis to investigate the amino acid composition of ribosomal proteins (r-proteins) with respect to their role in the assembly process. We compared small subunit (30S) r-protein sequences to those of other housekeeping proteins from 560 bacterial species and searched for correlations between r-protein amino acid content and factors such as assembly binding order, environmental growth temperature, protei

SUBMITTER: Lott BB 

PROVIDER: S-EPMC4016315 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature