Automated design of bacterial genome sequences.

ABSTRACT:

Background

Organisms have evolved ways of regulating transcription to better adapt to varying environments. Could the current functional genomics data and models support the possibility of engineering a genome with completely rearranged gene organization while the cell maintains its behavior under environmental challenges? How would we proceed to design a full nucleotide sequence for such genomes?

Results

As a first step towards answering such questions, recent work showed that it is possible to design alternative transcriptomic models showing the same behavior under environmental variations than the wild-type model. A second step would require providing evidence that it is possible to provide a nucleotide sequence for a genome encoding such transcriptional model. We used co

SUBMITTER: Carrera J 

PROVIDER: S-EPMC4016488 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature