Genomic profiling of type-1 adult diabetic and aged normoglycemic mouse liver.

ABSTRACT:

Background

Hyperglycemia induces chromatin remodeling with consequences on differential gene expression in mouse hepatocytes, similar to what occurs during aging. The liver is the central organ for the regulation of glucose homeostasis and xenobiotic and lipid metabolism and is affected by insulin signaling. The precise transcriptional profiling of the type-1 diabetic liver and its comparison to aging have not been elucidated yet.

Methods

Here, we studied the differential genomic expression of mouse liver cells under adult hyperglycemic and aged normoglycemic conditions using expression arrays.

Results

Differential gene expression involved in an increase in glucose and impaired lipid metabolism were detected in the type-1 diabetic liver. In this regard, Ppargc1a prese

SUBMITTER: Ghiraldini FG 

PROVIDER: S-EPMC4016577 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature