Inferring the effective TOR-dependent network: a computational study in yeast.

ABSTRACT:

Background

Calorie restriction (CR) is one of the most conserved non-genetic interventions that extends healthspan in evolutionarily distant species, ranging from yeast to mammals. The target of rapamycin (TOR) has been shown to play a key role in mediating healthspan extension in response to CR by integrating different signals that monitor nutrient-availability and orchestrating various components of cellular machinery in response. Both genetic and pharmacological interventions that inhibit the TOR pathway exhibit a similar phenotype, which is not further amplified by CR.

Results

In this paper, we present the first comprehensive, computationally derived map of TOR downstream effectors, with the objective of discovering key lifespan mediators, their crosstalk, and high-level

SUBMITTER: Mohammadi S 

PROVIDER: S-EPMC4016608 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature