Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays.

ABSTRACT:

Motivation

The recently released Infinium HumanMethylation450 array (the '450k' array) provides a high-throughput assay to quantify DNA methylation (DNAm) at ∼450 000 loci across a range of genomic features. Although less comprehensive than high-throughput sequencing-based techniques, this product is more cost-effective and promises to be the most widely used DNAm high-throughput measurement technology over the next several years.

Results

Here we describe a suite of computational tools that incorporate state-of-the-art statistical techniques for the analysis of DNAm data. The software is structured to easily adapt to future versions of the technology. We include methods for preprocessing, quality assessment and detection of differentially methylated regions from the kilobase

SUBMITTER: Aryee MJ 

PROVIDER: S-EPMC4016708 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature