Dataset Information
ChEpiMod: a knowledgebase for chemical modulators of epigenome reader domains.
Ontology highlight
ABSTRACT: Context
Epigenome reader domains are rapidly emerging as a new class of drug targets for a wide array of human diseases. To facilitate study of structure-activity relationship and small-molecule ligand design for these domains, we have created ChEpiMod. ChEpiMod is a free knowledgebase of chemical modulators with documented modulatory activity for epigenome reader domains.Methods
ChEpiMod organizes information about chemical modulators and their associated binding-affinity data, as well as available structures of epigenome readers from the Protein Data Bank. The data are gathered from the literature and patents. Entries are supplemented by annotation. The current version of ChEpiMod covers six epigenome reader domain families (Bromodomain, PHD finger, Chromodomain, MBT, PWWP and Tudor). The database can be used to browse existing chemical modulators and bioactivity data, as well as, all available structures of readers and their molecular interactions. The database is updated weekly.Availability
ChEpiMod is freely available at http://chepimod.orgContact
ming-ming.zhou@mssm.eduSupplementary information
Supplementary data is available at Bioinformatics online.
SUBMITTER: Meslamani J
PROVIDER: S-EPMC4016710 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Publications
ChEpiMod: a knowledgebase for chemical modulators of epigenome reader domains.
Bioinformatics (Oxford, England) 20140127 10
<h4>Context</h4>Epigenome reader domains are rapidly emerging as a new class of drug targets for a wide array of human diseases. To facilitate study of structure-activity relationship and small-molecule ligand design for these domains, we have created ChEpiMod. ChEpiMod is a free knowledgebase of chemical modulators with documented modulatory activity for epigenome reader domains.<h4>Methods</h4>ChEpiMod organizes information about chemical modulators and their associated binding-affinity data, ...[more]