ChEpiMod: a knowledgebase for chemical modulators of epigenome reader domains.

ABSTRACT:

Context

Epigenome reader domains are rapidly emerging as a new class of drug targets for a wide array of human diseases. To facilitate study of structure-activity relationship and small-molecule ligand design for these domains, we have created ChEpiMod. ChEpiMod is a free knowledgebase of chemical modulators with documented modulatory activity for epigenome reader domains.

Methods

ChEpiMod organizes information about chemical modulators and their associated binding-affinity data, as well as available structures of epigenome readers from the Protein Data Bank. The data are gathered from the literature and patents. Entries are supplemented by annotation. The current version of ChEpiMod covers six epigenome reader domain families (Bromodomain, PHD finger, Chromodomain, MBT, PWW

SUBMITTER: Meslamani J 

PROVIDER: S-EPMC4016710 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature