Gender specific association of RAS gene polymorphism with essential hypertension: a case-control study.

ABSTRACT: Renin-angiotensin system (RAS) polymorphisms have been studied as candidate risk factors for hypertension with inconsistent results, possibly due to heterogeneity among various genetic and environmental factors. A case-control association study was conducted to investigate a possible involvement of polymorphisms of three RAS genes: AGT M235T (rs699), ACE I/D (rs4340) and G2350A (rs4343), and AGTR1 A1166C (rs5186) in essential hypertensive patients. A total of 211 cases and 211 controls were recruited for this study. Genotyping was performed using PCR-RFLP method. The genotype and allele distribution of the M235T variant differed significantly in hypertensives and normotensives (OR-CI = 2.62 (1.24-5.76), P = 0.006; OR-CI = 0.699 (0.518-0.943), P = 0.018), respectively. When the samples were

SUBMITTER: Dhanachandra Singh Kh 

PROVIDER: S-EPMC4016835 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature