TRIM29 as a novel biomarker in pancreatic adenocarcinoma.

ABSTRACT:

Background and aim

Tripartite motif-containing 29 (TRIM29) is structurally a member of the tripartite motif family of proteins and is involved in diverse human cancers. However, its role in pancreatic cancer remains unclear.

Methods

The expression pattern of TRIM29 in pancreatic ductal adenocarcinoma was assessed by immunocytochemistry. Multivariate logistic regression analysis was used to investigate the association between TRIM29 and clinical characteristics. In vitro analyses by scratch wound healing assay and invasion assays were performed using the pancreatic cancer cell lines.

Results

Immunohistochemical analysis showed TRIM29 expression in pancreatic cancer tissues was significantly higher  (n = 186) than that in matched adjacent nontumor tissues. TRIM29 protei

SUBMITTER: Sun H 

PROVIDER: S-EPMC4016900 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature