Doublecortin-like kinase enhances dendritic remodelling and negatively regulates synapse maturation.

ABSTRACT: Dendritic morphogenesis and formation of synapses at appropriate dendritic locations are essential for the establishment of proper neuronal connectivity. Recent imaging studies provide evidence for stabilization of dynamic distal branches of dendrites by the addition of new synapses. However, molecules involved in both dendritic growth and suppression of synapse maturation remain to be identified. Here we report two distinct functions of doublecortin-like kinases, chimeric proteins containing both a microtubule-binding domain and a kinase domain in postmitotic neurons. First, doublecortin-like kinases localize to the distal dendrites and promote their growth by enhancing microtubule bundling. Second, doublecortin-like kinases suppress maturation of synapses through multiple pathways, inclu

SUBMITTER: Shin E 

PROVIDER: S-EPMC4017031 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature