Effect of hypoxia on lung gene expression and proteomic profile: insights into the pulmonary surfactant response.

ABSTRACT: Exposure of lung to hypoxia has been previously reported to be associated with significant alterations in the protein content of bronchoalveolar lavage (BAL) and lung tissue. In the present work we have used a proteomic approach to describe the changes in protein complement induced by moderate long-term hypoxia (rats exposed to 10% O2 for 72h) in BAL and lung tissue, with a special focus on the proteins associated with pulmonary surfactant, which could indicate adaptation of this system to limited oxygen availability. The analysis of the general proteomic profile indicates a hypoxia-induced increase in proteins associated with inflammation both in lavage and lung tissue. Analysis at mRNA and protein levels revealed no significant changes induced by hypoxia on the content in surfactant prot

SUBMITTER: Olmeda B 

PROVIDER: S-EPMC4017078 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature