Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development.

ABSTRACT: Proper regulation of keratinocyte differentiation within the epidermis and follicular epithelium is essential for maintenance of epidermal barrier function and hair growth. The signaling intermediates that regulate the morphological and genetic changes associated with epidermal and follicular differentiation remain poorly understood. We tested the hypothesis that reactive oxygen species (ROS) generated by mitochondria are an important regulator of epidermal differentiation by generating mice with a keratinocyte-specific deficiency in mitochondrial transcription factor A (TFAM), which is required for the transcription of mitochondrial genes encoding electron transport chain subunits. Ablation of TFAM in keratinocytes impaired epidermal differentiation and hair follicle growth and resulted i

SUBMITTER: Hamanaka RB 

PROVIDER: S-EPMC4017376 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature