Association of co-stimulatory human B-lymphocyte antigen B7-2 (CD86) gene polymorphism with colorectal cancer risk.

ABSTRACT:

Aim

This study investigated the role of CD86 +237 G/C polymorphism in intensifying the risk of CRC development.

Background

Colorectal cancer (CRC) is a multi-factorial diseases. Genetic background could affect the susceptibility of individuals to CRC development. CD86 is a co-stimulatory factor on antigen-presenting cells that plays key roles in several cancer related mechanisms such as autoimmunity, transplantation and tumor immunity.

Patients and methods

A total of 300 individuals, 150 known CRC patients and 150 healthy control individuals, were subjected for the study. CD86 rs17281995 single nucleotide polymorphism (SNP) was genotyped using Allelic Discrimination method.

Results

A statistically significant difference was found among CD86 gene polymorphism (r

SUBMITTER: Azimzadeh P 

PROVIDER: S-EPMC4017506 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature