The effect of 5'untranslated region polymorphism in EGF gene, rs4444903, on colorectal cancer.

ABSTRACT:

Aim

The purpose of this study was to determine the relationship of rs4444903 (EGF+61A/G) SNP genotype with colorectal cancer and tumor stage in an Iranian population.

Background

Epidermal growth factor (EGF) is one of the important proteins that determine survival of cells. EGF binds to its receptor on the cell surface and then activates some of the cell signaling pathway networks within cells that lead to activation or deactivation of factors which are responsible for growth and apoptosis of cells. In this study we assessed the association in EGF polymorphism rs4444903 with colorectal cancer (CRC) in Iranian population.

Patients and methods

We conducted case-control study to investigate the association of polymorphism rs4444903 in EGF, with colorectal cancer risk in

SUBMITTER: Chaleshi V 

PROVIDER: S-EPMC4017510 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature