Association of intron and exon polymorphisms of p53 gene in Iranian patients with gastritis.

ABSTRACT:

Aim

The propose of this study was to evaluate the probable correlation between exon and intron polymorphisms of p53 gene and their association with clinicopathological aspects of gastritis.

Background

Regarding to the decisive role of p53 in the development of a variety of human cancers, a comprehensive study concerning probable correlation between polymorphisms in the p53 intron and exon in gastritis lesions, may open new insight toward gastric cancer development and prevention.

Patients and methods

PCR-Sequencing was done for exons and introns 2-7 on the 97 gastritis and normal samples, age range of 15-83 years. Also, microsatellite status was evaluated using five mono nucleotide repeat markers. Variation at codon 72 was associated with IVS2 + 38, p53INS3 and IVS3-2

SUBMITTER: Najjar Sadeghi R 

PROVIDER: S-EPMC4017528 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature