Single nucleotide polymorphisms associated with abnormal coronary microvascular function.

ABSTRACT:

Background

Single nucleotide polymorphisms (SNPs) are the most common source of genetic variation. Although microvascular pathology is associated with cardiovascular events, genetic phenotypes causing microvascular disease remain largely unknown. This study identifies sex-specific SNPs associated with coronary microvascular dysfunction.

Methods and results

Six hundred and forty-three patients without significant obstructive coronary heart disease were enrolled, referred for cardiac catheterization, and underwent invasive coronary microcirculatory assessment. Patient data were collected from 1529 autosomal SNPs and seven X chromosome SNPs, which were selected to represent the variability from 76 candidate genes with published associations with coronary vasoreactivity, angioge

SUBMITTER: Yoshino S 

PROVIDER: S-EPMC4017593 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature